Building on the collective wisdom of using evidence to generate impact in 2020, the campaign for World EBHC Day 2021 explores the role of evidence in an infodemic, in particular promoting access to trustworthy, evidence-informed health information. In 2021, we call on the global evidence community to share their experiences, expertise and stories on infodemic management, including facilitating accurate knowledge translation; knowledge refinement, filtering and fact-checking; building eHealth/science literacy; and monitoring, infoveillance and social listening.